Regular consumptionpermanently alters the molecular functioning of cells. place in memory . This is a larger It is likely to facilitate learning and improve memory.
Many people drink coffee. Some do it for taste, many for the stimulating properties of caffeine. Indeed, the latter increases alertness and concentration in the hours following its consumption. It also has an effect on memory: several epidemiological and experimental studies,. In fact, a phase 3 study was initiated in Lille in 2021 to evaluate the effect of caffeine on the cognitive functions of patients with the early or intermediate form of this neurodegenerative disease ( ).
However, the underlying molecular mechanisms were unknown. That’s why David Blum’s Lille Neuroscience &(unit 1172 Inserm/University of Lille/CHU of Lille) and Anne-Laurence Boutillier at the Strasbourg Cognitive and Adaptive Neurosciences Laboratory (UMR7364 CNRS/University of Strasbourg) have decided to tackle this problem. chronic caffeine consumption in mice. Their work was published in the journal .
Caffeinated and decaffeinated mice
” Many studies have been done on this substance, but they have mostly focused on acute consumption, i.e. occasional consumption, and not chronic consumption as is usually observed. Additionally, these studies do not provide information about the downstream induced molecular changes when caffeine is fixed to its receptors in the brain. The aim of our project was to understand all this. “, they explain.
In the experimental mouse model, the researchers focused their work on the hippocampus, a brain structure that is the main area of memory and is affected in the brain.. They gave the animals a moderate dose of caffeine orally every day. in humans. After two weeks on this diet, the researchers examined the hippocampus cells. A priori.
They analyzed their expression profile.(transcriptomic analyses), chemical modifications of proteins bound to proteins likely to alter this expression (epigenetic analyses) or the nature of proteins and others. found in cells (proteomics and metabolomics). This study was conducted in resting animals and others subjected to a learning task. The results obtained were compared with those observed in mice that did not receive the drug. .
Caffeine “traces” in the hippocampus?
These results, which are quite rich in terms of descriptive terms, allow for various observations. First of all, caffeine leaves long-term molecular “traces” in the body.especially at the epigenetic level. And these traces are not the same depending on the cell type. For example, some metabolic pathways appear to be downmodulated in non-neuronal cells of the hippocampus. ), while the activity of other pathways increases, . The most interesting, however, concerns observations made in a learning situation.
The most interesting relates to observations made in a learning situation.
” As expected during a missionTranscriptional activity is increased in the hippocampus, reflecting the level of gene expression. This is normal as this structure is mobilized to memorize this task. However, we see that this increase is much stronger in animals that regularly consume caffeine.
On closer inspection, the metabolic pathways reduced by caffeine in the glial cells while the animals are at rest become activated when they are finally activated.. And those that are activated in neurons are activated even more strongly. These data suggest that caffeine acts as a facilitator of the hippocampal response to a memory task, through concerted action at the level of neuronal and non-neuronal cells. Ends David Blum.
Drinking coffee is good for memory
More than a stimulant, coffee improves memory for at least a day. In any case, it’s the result of a new study that should encourage students to drink coffee in moderation the day before exams.
Article from Destination Santé, published January 13, 2014
If coffee has a less good reputation, is not bad for health, quite the contrary. Studies have shown that coffee reduces the risk of developing certain pathologies, such as stroke. ) and specific . previous work National Cancer Institute (NCI) also reported that people aged 50 to 71 who drank an average of three cups of coffee a day were better protected against the risk of death. and respiratory diseases, strokes, injuries, accidents, diabetes and even infections. Caffeine consumption will also be associated with a longer healthy life and have protective effects against cognitive decline that occurs during childbirth. .
In a new study published in the journalResearchers at Johns-Hopkins University in Baltimore (USA) have discovered a new virtue of one of the world’s most consumed beverages. For them, coffee would stimulate memory, an effect never seen before.
Coffee to better identify visual differences
To achieve this result, the team recruited 73 volunteers and asked them to view various images representing objects. After this operation was performed, half of the group was given a dose of 200 milligrams of caffeine, the equivalent of two cups of coffee.and the other half . The next day, the researchers asked both groups to look at another set of images. Some were the same as the previous day, some were new and some were similar but there were some differences.
Both groups were equally good at distinguishing between old and new images. However, those who consumethey were more successful at detecting differences in similar images. Therefore, this study on at least 24 hours.
“We wouldn’t have discovered this effect of caffeine had we done a standard memory test experiment without using similar images.explains Michael Yassa, the director of this study. With these images that are difficult to distinguish,must take on a somewhat more difficult task. » Therefore this process is called of the fully fortified model with caffeine.